Renal cancer pertinent cancer susceptibility
Gene: MET

MET (MET proto-oncogene, receptor tyrosine kinase)
EnsemblGeneIds (GRCh38): ENSG00000105976
EnsemblGeneIds (GRCh37): ENSG00000105976
OMIM: 164860, Gene2Phenotype
MET is in 10 panels

2 reviews

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Renal

Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Created: 20 Jul 2017, 1:36 p.m.

Panel version: Imported from "Solid tumours" panel version 0.4

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.
Created: 26 Jul 2017, 12:14 p.m.

Comment on mode of pathogenicity: Activating variants.
Created: 19 Jul 2017, 3:49 p.m.

Created: 19 Jul 2017, 3:49 p.m.

Panel version: 0.4

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green
Expert list

Phenotypes

Renal cancer

OMIM

164860

Clinvar variants

Variants in MET

Penetrance

Complete

Mode of Pathogenicity

Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Panels with this gene

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on mode of pathogenici

26 Jul 2017, Gel status: 4