Unexplained kidney failure in young people
Gene: REN
REN (renin)
EnsemblGeneIds (GRCh38): ENSG00000143839
EnsemblGeneIds (GRCh37): ENSG00000143839
OMIM: 179820, Gene2Phenotype
REN is in 7 panels
EnsemblGeneIds (GRCh38): ENSG00000143839
EnsemblGeneIds (GRCh37): ENSG00000143839
OMIM: 179820, Gene2Phenotype
REN is in 7 panels
1 review
Sarah Leigh (Genomics England Curator)
Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least four variants reported in Renal tubular dysgenesis 267430, two in Hyperuricemic nephropathy, familial juvenile 2 613092 and one in HyperproreninemiaCreated: 5 Aug 2016, 9:36 a.m.
Details
- Mode of Inheritance
- BOTH monoallelic and biallelic, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- UKGTN
- Expert list
- Radboud University Medical Center, Nijmegen
- Illumina TruGenome Clinical Sequencing Services
- Phenotypes
-
- Hyperuricemic nephropathy, familial juvenile 2 613092
- Renal tubular dysgenesis 267430
- [Hyperproreninemia]
- OMIM
- 179820
- Clinvar variants
- Variants in REN
- Penetrance
- Complete
- Panels with this gene
History Filter Activity
17 Aug 2016, Gel status: 4
panel promoted to version 1
Sarah Leigh (Genomics England Curator)Promoted to version 1 17th August 2016
5 Aug 2016, Gel status: 4
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
5 Aug 2016, Gel status: 4
Upload gene information
Sarah Leigh (Genomics England Curator)REN was added to Unexplained kidney failure in young peoplepanel. Sources: UKGTN
27 Jun 2016, Gel status: 4
Set Phenotypes
Sarah Leigh (Genomics England Curator)Phenotypes for REN were set to Hyperuricemic nephropathy, familial juvenile 2 613092; Renal tubular dysgenesis 267430; [Hyperproreninemia]
18 May 2016, Gel status: 4
Added New Source
Sarah Leigh (Genomics England Curator)REN was added to Unexplained kidney failure in young peoplepanel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Expert list,Expert Review Green
18 May 2016, Gel status: 0
Created
Sarah Leigh (Genomics England Curator)REN was created by sleigh