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Unexplained kidney failure in young people

Gene: WT1

Green List (high evidence)

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 21 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM and G2P. At least five variants reported
Created: 5 Aug 2016, 1:17 p.m.
Comment on phenotypes: Also associated with Denys-Drash syndrome 194080, Frasier syndrome 136680, Meacham syndrome 608978, Mesothelioma, somatic 156240; Wilms tumor, type 1 194070
Created: 5 Aug 2016, 1:16 p.m.
Comment on list classification: Promoted from Red to Green because this gene is Green in Version 1 of the Proteinuric renal disease gene panel
Created: 17 Jun 2016, 9:29 a.m.

History Filter Activity

30 Jan 2019, Gel status: 3

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: WT1 were changed from Nephrotic syndrome, type 4 256370 to Nephrotic syndrome, type 4 256370

17 Aug 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Promoted to version 1 17th August 2016

5 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

5 Aug 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for WT1 were set to Nephrotic syndrome, type 4 256370

5 Aug 2016, Gel status: 4

Upload gene information

Sarah Leigh (Genomics England Curator)

WT1 was added to Unexplained kidney failure in young peoplepanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN

20 Jun 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for WT1 were set to Nephrotic syndrome, type 4 256370

20 Jun 2016, Gel status: 4

Set Mode of Inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

17 Jun 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

16 May 2016, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

WT1 was created by sleigh

16 May 2016, Gel status: 0

Added New Source

Sarah Leigh (Genomics England Curator)

WT1 was added to Unexplained kidney failure in young peoplepanel. Sources: Eligibility statement prior genetic testing