APOL1 kidney donor testing
Gene: APOL1

APOL1 (apolipoprotein L1)
EnsemblGeneIds (GRCh38): ENSG00000100342
EnsemblGeneIds (GRCh37): ENSG00000100342
OMIM: 603743, Gene2Phenotype
APOL1 is in 5 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

The rating of this gene has been updated to green and the mode of inheritance set to BIALLELIC, autosomal or pseudoautosomal following NHS Genomic Medicine Service approval.
Created: 26 Sep 2024, 12:16 p.m. | Last Modified: 26 Sep 2024, 12:16 p.m.

Panel Version: 0.3

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 26 Sep 2024, 12:16 p.m.
Last Modified: 26 Sep 2024, 12:16 p.m.
Panel version: 0.3

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

APOL1 has been added to the panel for R446 APOL1 kidney donor testing with a green rating as agreed with the NHS Genomic Medicine Service.
Sources: NHS GMS
Created: 13 Aug 2024, 10:34 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
{Glomerulosclerosis, focal segmental, 4, susceptibility to}, OMIM:612551

Created: 13 Aug 2024, 10:34 a.m.

Panel version: 0.1

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Green
NHS GMS

Phenotypes

{Glomerulosclerosis, focal segmental, 4, susceptibility to}, OMIM:612551

OMIM

603743

Clinvar variants

Variants in APOL1

Penetrance

None

Panels with this gene

History Filter Activity

26 Sep 2024, Gel status: 3

Added New Source, Status Update

Sarah Leigh (Genomics England Curator)

Source Expert Review Green was added to APOL1. Rating Changed from Red List (low evidence) to Green List (high evidence)

13 Aug 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: APOL1 was added gene: APOL1 was added to APOL1 kidney donor testing. Sources: NHS GMS Mode of inheritance for gene: APOL1 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: APOL1 were set to {Glomerulosclerosis, focal segmental, 4, susceptibility to}, OMIM:612551 Review for gene: APOL1 was set to GREEN

APOL1 kidney donor testing Gene: APOL1