Insulin resistance (including lipodystrophy)

Gene: LIPE

Green List (high evidence)

LIPE (lipase E, hormone sensitive type)
EnsemblGeneIds (GRCh38): ENSG00000079435
EnsemblGeneIds (GRCh37): ENSG00000079435
OMIM: 151750, Gene2Phenotype
LIPE is in 2 panels

1 review

Ivone Leong (Genomics England Curator)

Green List (high evidence)

Keven Colclough (Royal Devon & Exeter Hospital) has recommended that this gene be included in this panel. LIPE is a green gene in the Lipodystrophy - childhood onset panel (Version 1.0). LIPE is confirmed to be associated to partial familial lipodystrophy in OMIM but not in Gene2Phenotype. There are 3 unrelated cases of patients with partial lipodystrophy with different variants in the LIPE gene.
Sources: Expert list
Created: 8 Jan 2019, 3:43 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal



Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • Expert Review Green
  • Expert list
Clinvar variants
Variants in LIPE
Panels with this gene

History Filter Activity

8 Jan 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: lipe has been classified as Green List (High Evidence).

8 Jan 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Ivone Leong (Genomics England Curator)

gene: LIPE was added gene: LIPE was added to Insulin resistance (including lipodystrophy). Sources: Expert list Mode of inheritance for gene: LIPE was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: LIPE were set to 27862896; 25475467; 24848981 Review for gene: LIPE was set to GREEN