Insulin resistance (including lipodystrophy)

Gene: WRN

Green List (high evidence)

WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 16 panels

2 reviews

Robert Semple (University of Cambridge)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. Numerous variants reported. Werner syndrome 27770 does not include Acanthosis nigricans
Created: 12 Aug 2016, 8:24 a.m.

History Filter Activity

12 Aug 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Promoted to version 1 12/08/2016

12 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

12 Aug 2016, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for WRN were set to 8602509

12 Aug 2016, Gel status: 4

Upload gene information

Sarah Leigh (Genomics England Curator)

WRN was added to Insulin resistance (including lipodystrophy)panel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen

12 Aug 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for WRN were set to Werner syndrome 277700

12 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

12 Oct 2015, Gel status: 0

Added New Source

Robert Semple (University of Cambridge)

WRN was added to Insulin resistance (including lipodystrophy) panel. Sources: Literature