Primary ciliary disorders

Gene: LZTFL1

Amber List (moderate evidence)

LZTFL1 (leucine zipper transcription factor like 1)
EnsemblGeneIds (GRCh38): ENSG00000163818
EnsemblGeneIds (GRCh37): ENSG00000163818
OMIM: 606568, Gene2Phenotype
LZTFL1 is in 18 panels

2 reviews

Eleanor Williams (Genomics England Curator)

Leaving LZTFL1 Amber on this panel for now because only one family to date has been reported with situs inversus / dextrocardia (phenotype associated with motile cilia). It is green on the Rare multisystem ciliopathy disorders which covers non-motile ciliopathies.
Created: 21 Dec 2018, 11:33 a.m.

Helen Brittain (Genomics England Curator)

I don't know

Comment on list classification: Unclear. Further evidence needed of implication of gene in disease and also whether the phenotype is relevant to this panel. Watchlist.
Created: 4 Jul 2017, 7:28 a.m.
Two unrelated families with BBS reported to date, one family had situs anomalies. Not clear if this is linked to this gene, or a separate cause. Insufficient evidence for inclusion under situs inversus phenotype at present.
Created: 4 Jul 2017, 7:25 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Visceral Heterotaxy; Bardet-Biedl Syndrome 17

Publications

History Filter Activity

9 Nov 2021, Gel status: 2

Set Phenotypes, Set publications

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: LZTFL1 were changed from Visceral Heterotaxy; Bardet-Biedl Syndrome 17 to Visceral Heterotaxy; Bardet-Biedl Syndrome 17 Publications for gene: LZTFL1 were updated from 22510444; 23692385 to 22510444; 23692385

4 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Helen Brittain (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

4 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Helen Brittain (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

4 Jul 2017, Gel status: 0

Created

Helen Brittain (Genomics England Curator)

LZTFL1 was created by helen.brittain

4 Jul 2017, Gel status: 1

Added New Source

Helen Brittain (Genomics England Curator)

LZTFL1 was added to Primary ciliary disorderspanel. Sources: UKGTN