Genes in panel

STRs in panel

Prev Next

Regions in panel

Prev Next

This Panel is marked as Internal

Genomic imprinting
Gene: GRB10

GRB10 (growth factor receptor bound protein 10)
EnsemblGeneIds (GRCh38): ENSG00000106070
EnsemblGeneIds (GRCh37): ENSG00000106070
OMIM: 601523, Gene2Phenotype
GRB10 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene, GRB10, has been associated with Silver-Russell syndrome 2, OMIM:618905 in cases with duplication of 7p including GRB10 (PMID: 10631135;12384779;10987657;33187293).
Created: 21 Jan 2022, 7:54 a.m. | Last Modified: 21 Jan 2022, 7:58 a.m.

Panel Version: 0.123

Imprinted, isoform-specific expression.
Created: 22 Dec 2020, 6:10 p.m. | Last Modified: 22 Dec 2020, 6:10 p.m.

Panel Version: 0.26

Publications

Created: 22 Dec 2020, 6:10 p.m.
Last Modified: 21 Jan 2022, 7:58 a.m.
Panel version: 0.122

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)

Sources

Expert Review Green
Literature

Phenotypes

Silver-Russell syndrome 2, OMIM:618905

OMIM

Clinvar variants

Variants in GRB10

Penetrance

None

Publications

Panels with this gene

Multi locus imprinting disorders

History Filter Activity

21 Jan 2022, Gel status: 3

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: grb10 has been classified as Green List (High Evidence).

21 Jan 2022, Gel status: 2

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: GRB10 were changed from Silver-Russell syndrome to Silver-Russell syndrome 2, OMIM:618905

21 Jan 2022, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: GRB10 were set to 10861285; 10856193; 27370225; 10856193; 11112662; 30794780; 29455159; http://igc.otago.ac.nz/home.html

21 Jan 2022, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: GRB10 were set to 10861285; 10856193; 27370225; 10856193; 11112662; 30794780; http://igc.otago.ac.nz/home.html

20 Jan 2022, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: grb10 has been classified as Amber List (Moderate Evidence).

20 Jan 2022, Gel status: 1

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for gene: GRB10 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)

20 Jan 2022, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: GRB10 were changed from to Silver-Russell syndrome

20 Jan 2022, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: GRB10 were set to 30794780; http://igc.otago.ac.nz/home.html

22 Dec 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: GRB10 was added gene: GRB10 was added to Imprinted Genes. Sources: Literature Mode of inheritance for gene: GRB10 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: GRB10 were set to 30794780; http://igc.otago.ac.nz/home.html