| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Genomic imprinting v0.125 | GRB10 | Sarah Leigh Classified gene: GRB10 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.125 | GRB10 | Sarah Leigh Gene: grb10 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.124 | GRB10 | Sarah Leigh Phenotypes for gene: GRB10 were changed from Silver-Russell syndrome to Silver-Russell syndrome 2, OMIM:618905 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.123 | GRB10 | Sarah Leigh changed review comment from: Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene, GRB10, has been associated with Silver-Russell Syndrome in cases with duplication of 7p including GRB10 (PMID: 10631135;12384779;10987657;33187293).; to: Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene, GRB10, has been associated with Silver-Russell syndrome 2, OMIM:618905 in cases with duplication of 7p including GRB10 (PMID: 10631135;12384779;10987657;33187293). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.123 | GRB10 | Sarah Leigh Publications for gene: GRB10 were set to 10861285; 10856193; 27370225; 10856193; 11112662; 30794780; 29455159; http://igc.otago.ac.nz/home.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.122 | GRB10 | Sarah Leigh edited their review of gene: GRB10: Added comment: Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene, GRB10, has been associated with Silver-Russell Syndrome in cases with duplication of 7p including GRB10 (PMID: 10631135;12384779;10987657;33187293).; Changed rating: GREEN; Changed publications to: 10631135, 12384779, 10987657, 33187293 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.122 | GRB10 | Sarah Leigh Deleted their comment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.122 | GRB10 | Sarah Leigh Publications for gene: GRB10 were set to 10861285; 10856193; 27370225; 10856193; 11112662; 30794780; http://igc.otago.ac.nz/home.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.117 | GRB10 | Sarah Leigh Classified gene: GRB10 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.117 | GRB10 | Sarah Leigh Gene: grb10 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.116 | GRB10 | Sarah Leigh Mode of inheritance for gene: GRB10 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.115 | GRB10 | Sarah Leigh Phenotypes for gene: GRB10 were changed from to Silver-Russell syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.114 | GRB10 | Sarah Leigh Publications for gene: GRB10 were set to 30794780; http://igc.otago.ac.nz/home.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.113 | GRB10 | Sarah Leigh edited their review of gene: GRB10: Added comment: Not associated with a phenotype in OMIM, Gen2Phen or MONDO. GRB10 is imprinted in specific tissues and not in others (PMID:10861285). Although GRB10 has been associated with Russell-Silver Syndrome (RSS), with a 574 kb duplication at chromosome 7p12.1 (PMID: 27370225) and a report of the variant p.P95S in the maternal allele of two unrelated cases of RSS (PMID: 10856193); it would appear that this is a rare occurrence and not supported by the maternal uniparental disomy of 7q31-qter and biparental inheritance of the rest of chromosome 7 in another case of RSS (PMID: 11112662).; Changed publications to: 10861285, 10856193, 27370225, 10856193, 11112662 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.26 | GRB10 | Sarah Leigh reviewed gene: GRB10: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic imprinting v0.22 | GRB10 |
Sarah Leigh gene: GRB10 was added gene: GRB10 was added to Imprinted Genes. Sources: Literature Mode of inheritance for gene: GRB10 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: GRB10 were set to 30794780; http://igc.otago.ac.nz/home.html |
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