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Genomic imprinting

Gene: MEG3

Green List (high evidence)
MEG3 (maternally expressed 3 (non-protein coding))
EnsemblGeneIds (GRCh38): ENSG00000214548
EnsemblGeneIds (GRCh37): ENSG00000214548
OMIM: 605636, Gene2Phenotype
MEG3 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene MEG3 has been associated with multiple cases of Temple syndrome (PMID: 33010492;33746039) and to Kagami-Ogata syndrome (PMID: 33067531).
Created: 21 Jan 2022, 8:33 a.m. | Last Modified: 21 Jan 2022, 8:33 a.m.
Panel Version: 0.126
PiRNAs (Piwi-interacting RNAs) at 14q32 (DLK1-MEG3(GTL2)) are homologous with several human 14q(I) and 14(II) C/D RNA sequences (PMID 18271756)(http://igc.otago.ac.nz). Circadian expression reported in CircaDB (http://circadb.hogeneschlab.org/human)
Created: 22 Dec 2020, 6:10 p.m. | Last Modified: 22 Dec 2020, 6:10 p.m.
Panel Version: 0.26

Publications

Created: 22 Dec 2020, 6:10 p.m.
Last Modified: 22 Dec 2020, 6:10 p.m.
Panel version: 0.126

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Temple syndrome, OMIM:616222
  • Kagami-Ogata syndrome, OMIM:608149
Tags
locus-type-rna-long-non-coding
OMIM
605636
Clinvar variants
Variants in MEG3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

30 Jul 2024, Gel status: 3

Added Tag

Sarah Leigh (Genomics England Curator)

Tag locus-type-rna-long-non-coding tag was added to gene: MEG3.

21 Jan 2022, Gel status: 3

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: MEG3 were changed from Kagami-Ogata syndrome, OMIM:608149; Temple syndrome, OMIM:616222 to Temple syndrome, OMIM:616222; Kagami-Ogata syndrome, OMIM:608149

21 Jan 2022, Gel status: 3

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html; 29641995

21 Jan 2022, Gel status: 3

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: meg3 has been classified as Green List (High Evidence).

21 Jan 2022, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: MEG3 were changed from to Kagami-Ogata syndrome, OMIM:608149; Temple syndrome, OMIM:616222

12 Jan 2021, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html

22 Dec 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: MEG3 was added gene: MEG3 was added to Imprinted Genes. Sources: Literature Mode of inheritance for gene: MEG3 was set to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed) Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html