Gene: SLIT2

Amber List (moderate evidence)

SLIT2 (slit guidance ligand 2)
EnsemblGeneIds (GRCh38): ENSG00000145147
EnsemblGeneIds (GRCh37): ENSG00000145147
OMIM: 603746, Gene2Phenotype
SLIT2 is in 3 panels

3 reviews

Catherine Snow (Genomics England)

Comment on list classification: Gene identified as missing from panel by expert reviewer. Rating as Amber as gene disease only reported in PMID:26026792 no further evidence of this association and missing segregation information for some of the three individuals.
Created: 21 May 2020, 10:52 a.m. | Last Modified: 21 May 2020, 10:52 a.m.
Panel Version: 1.126

Zornitza Stark (Australian Genomics)

Green List (high evidence)

Three unrelated individuals reported in this cohort.
Created: 16 Jan 2020, 4:38 a.m. | Last Modified: 16 Jan 2020, 4:38 a.m.
Panel Version: 1.41

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted



Variants in this GENE are reported as part of current diagnostic practice

Helen Stuart (University of Manchester)

Red List (low evidence)


  • Expert Review Amber
  • Expert list
Clinvar variants
Variants in SLIT2
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: slit2 has been classified as Amber List (Moderate Evidence).

21 May 2020, Gel status: 1

Set publications

Catherine Snow (Genomics England)

Publications for gene: SLIT2 were set to

22 Apr 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

14 Jul 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

SLIT2 was added to Congenital Anomaly of the Kidneys and Urinary Tract (CAKUT)panel. Sources: Expert list