Glaucoma (developmental)
Gene: NTF4

NTF4 (neurotrophin 4)
EnsemblGeneIds (GRCh38): ENSG00000225950
EnsemblGeneIds (GRCh37): ENSG00000225950
OMIM: 162662, Gene2Phenotype
NTF4 is in 2 panels

2 reviews

Nicola Ragge (Birmingham Women's and Children's NHS Foundation Hospital Trust)

Red List (low evidence)

glaucoma gene, can't find any evidence that it is associated with structural eye disease - glaucoma seems adult-onset
Created: 19 Jun 2019, 3:32 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
GLAUCOMA 1, OPEN ANGLE, O; 613100

Mode of pathogenicity
Other - please provide details in the comments

Created: 19 Jun 2019, 3:32 p.m.

Panel version: Imported from Structural eye disease panel version 0.76

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Submitted on behalf of Professor Nicola Ragge (Wessex and West Midlands GLH). glaucoma gene, can't find any evidence that it is associated with structural eye disease - glaucoma seems adult-onset
Created: 17 Apr 2019, 3:30 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
GLAUCOMA 1, OPEN ANGLE, O, 613100

Mode of pathogenicity
Other - please provide details in the comments

Created: 17 Apr 2019, 3:30 p.m.

Panel version: Imported from Structural eye disease panel version 0.48

Details

Sources

NHS GMS
Radboud University Medical Center, Nijmegen

Phenotypes

Glaucoma 1, open angle, 1O, 613100

OMIM

162662

Clinvar variants

Variants in NTF4

Penetrance

Complete

Panels with this gene

History Filter Activity

27 Apr 2017, Gel status: 1

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

27/04/2017: Revised after review and further curation, with clinical input, and promoted to version 1.

11 May 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

NTF4 was added to Glaucoma (developmental)panel. Sources: Radboud University Medical Center, Nijmegen

Glaucoma (developmental) Gene: NTF4