Congenital disorders of glycosylation
Gene: MOGSEnsemblGeneIds (GRCh38): ENSG00000115275
EnsemblGeneIds (GRCh37): ENSG00000115275
OMIM: 601336, Gene2Phenotype
MOGS is in 10 panels
3 reviews
Rebecca Foulger (Genomics England curator)
GlyGen link: https://www.glygen.org/protein_detail.html?uniprot_canonical_ac=Q13724-1Created: 9 Jan 2020, 2:39 p.m. | Last Modified: 9 Jan 2020, 2:39 p.m.
Panel Version: 2.0
Sarah Leigh (Genomics England Curator)
Comment on list classification: Promotion of this gene from amber to green on this panel is appropriate, based on the review in the Undiagnosed metabolic disorders panel including additional variants reportedCreated: 21 Mar 2017, 11:44 a.m.
Comment when marking as ready: Associated with phenotype in OMIM and as a probable Developmental Disorder Gene / G2P. At least 4 variants reported as compound heterozygotes in two families.Created: 19 Dec 2016, 10:32 a.m.
Daniel Ungar (University of York, Department of Biology)
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- UKGTN
- Radboud University Medical Center, Nijmegen
- Literature
- Illumina TruGenome Clinical Sequencing Services
- Emory Genetics Laboratory
- Phenotypes
-
- Congenital disorder of glycosylation, type IIb 606056
- MOGS-CDG (Disorders of protein N-glycosylation)
- OMIM
- 601336
- Clinvar variants
- Variants in MOGS
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Congenital disorders of glycosylation
- Likely inborn error of metabolism
- Childhood onset dystonia, chorea or related movement disorder
- Intellectual disability
- COVID-19 research
- Undiagnosed metabolic disorders
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Fetal anomalies
- DDG2P
- Early onset or syndromic epilepsy
History Filter Activity
Set publications
Sarah Leigh (Genomics England Curator)Publications for MOGS were set to 4716661; 24716661; 20301507;26805780
Set Phenotypes
Sarah Leigh (Genomics England Curator)Phenotypes for MOGS were set to Congenital disorder of glycosylation, type IIb 606056; MOGS-CDG (Disorders of protein N-glycosylation)
Set publications
Sarah Leigh (Genomics England Curator)Publications for MOGS were set to 4716661;24716661;20301507
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
panel promoted to version 1
Sarah Leigh (Genomics England Curator)Promoted to V1 19th December 2016
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Amber List (Moderate Evidence).
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Amber List (Moderate Evidence).
Added New Source
Sarah Leigh (Genomics England Curator)MOGS was added to Congenital disorders of glycosylationpanel. Source: UKGTN
Added New Source
Sarah Leigh (Genomics England Curator)MOGS was added to Congenital disorders of glycosylationpanel. Source: Radboud University Medical Center, Nijmegen
Set Mode of Inheritance, Added New Source
Sarah Leigh (Genomics England Curator)MOGS was added to Congenital disorders of glycosylationpanel. Source: Literature Model of inheritance for gene MOGS was set to BIALLELIC, autosomal or pseudoautosomal
Added New Source
Sarah Leigh (Genomics England Curator)MOGS was added to Congenital disorders of glycosylationpanel. Source: Illumina TruGenome Clinical Sequencing Services
Added New Source
Sarah Leigh (Genomics England Curator)MOGS was added to Congenital disorders of glycosylationpanel. Sources: Emory Genetics Laboratory
Created
Sarah Leigh (Genomics England Curator)MOGS was created by sleigh