DNA Repair Genes pertinent cancer susceptibility
Gene: MPLKIP

MPLKIP (M-phase specific PLK1 interacting protein)
EnsemblGeneIds (GRCh38): ENSG00000168303
EnsemblGeneIds (GRCh37): ENSG00000168303
OMIM: 609188, Gene2Phenotype
MPLKIP is in 9 panels

1 review

Louise Daugherty (Genomics England Curator)

changed gene symbol to approved gene symbol MPLKIP. Original gene from http://sciencepark.mdanderson.org/labs/wood/dna_repair_genes.html was listed as TTDN1 (C7orf11), TTDN1 is a Synonym and C7orf11 is a previous approved gene symbol.
Created: 4 Aug 2017, 9:17 a.m.

Created: 4 Aug 2017, 9:17 a.m.

Panel version: 0.8

Details

Sources

Human DNA Repair Genes Database

Phenotypes

Class: Genes defective in diseases associated with sensitivity to DNA damaging agents
Activity: non-photosensitive form of trichothiodystrophy

OMIM

609188

Clinvar variants

Variants in MPLKIP

Penetrance

Complete

Panels with this gene

History Filter Activity

7 Sep 2018, Gel status: 1

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Louise Daugherty: changed gene symbol to approve

4 Aug 2017, Gel status: 0

Changed Gene Name

Louise Daugherty (Genomics England Curator)

TTDN1* was changed to MPLKIP

21 Jun 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

TTDN1* was created by ellenmcdonagh