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  2. Early onset dementia (encompassing fronto-temporal dementia and prion disease)
  3. FUS
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Early onset dementia (encompassing fronto-temporal dementia and prion disease)

Gene: FUS

Red List (low evidence)
FUS (FUS RNA binding protein)
EnsemblGeneIds (GRCh38): ENSG00000089280
EnsemblGeneIds (GRCh37): ENSG00000089280
OMIM: 137070, Gene2Phenotype
FUS is in 3 panels

2 reviews

simon mead (UCL)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
ALS

Caroline Wright (Genomics England Curator)

Comment on list classification: Comment on list classification: Associated with ALS and on ALS panel; not definitely associated with FTLD in OMIM, ClinVar or literature - mostly ALS patients without dementia
Created: 10 May 2016, 2:34 p.m.

History Filter Activity

10 May 2016, Gel status: 1

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

10 May 2016, Gel status: 1

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

27 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

FUS was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: UKGTN