Early onset dementia (encompassing fronto-temporal dementia and prion disease)
Gene: GRNEnsemblGeneIds (GRCh38): ENSG00000030582
EnsemblGeneIds (GRCh37): ENSG00000030582
OMIM: 138945, Gene2Phenotype
GRN is in 15 panels
2 reviews
simon mead (UCL)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Caroline Wright (Genomics England Curator)
Comment on list classification: Lots of cases in OMIM, in eligibility criteriaCreated: 10 May 2016, 11:41 a.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Expert Review Green
- Eligibility statement prior genetic testing
- UKGTN
- Illumina TruGenome Clinical Sequencing Services
- Phenotypes
-
- Frontotemporal Dementia
- Clinical syndrome FTLD (Frontotemporal lobar degeneration)
- OMIM
- 138945
- Clinvar variants
- Variants in GRN
- Penetrance
- Complete
- Panels with this gene
-
- Intellectual disability
- Likely inborn error of metabolism
- Neuronal ceroid lipofuscinosis
- Hereditary ataxia with onset in adulthood
- Structural eye disease
- Early onset dementia (encompassing fronto-temporal dementia and prion disease)
- Adult onset neurodegenerative disorder
- Adult onset dystonia, chorea or related movement disorder
- Retinal disorders
- Parkinson Disease and Complex Parkinsonism
- Glaucoma (developmental)
- Ataxia and cerebellar anomalies - narrow panel
- Amyotrophic lateral sclerosis/motor neuron disease
- Arthrogryposis
- Early onset or syndromic epilepsy
History Filter Activity
Gene classified by Genomics England curator
Caroline Wright (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Gene classified by Genomics England curator
Caroline Wright (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Added New Source
Ellen McDonagh (Genomics England Curator)GRN was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: Eligibility statement prior genetic testing
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene GRN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene GRN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene GRN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Added New Source
Ellen McDonagh (Genomics England Curator)GRN was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN
Added New Source
Ellen McDonagh (Genomics England Curator)GRN was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN