Early onset dementia (encompassing fronto-temporal dementia and prion disease)

Gene: PRNP

Green List (high evidence)

PRNP (prion protein)
EnsemblGeneIds (GRCh38): ENSG00000171867
EnsemblGeneIds (GRCh37): ENSG00000171867
OMIM: 176640, Gene2Phenotype
PRNP is in 14 panels

2 reviews

simon mead (UCL)

Green List (high evidence)

Caroline Wright (Genomics England Curator)

Comment on list classification: Prion disease gene, in eligibility criteria
Created: 10 May 2016, 12:41 p.m.

History Filter Activity

10 May 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 May 2016, Gel status: 4

Set publications

Caroline Wright (Genomics England Curator)

Publications for PRNP were set to 26791950;20583301

10 May 2016, Gel status: 4

Set Mode of Inheritance

Caroline Wright (Genomics England Curator)

Mode of inheritance for PRNP was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

10 May 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

12 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

PRNP was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: Eligibility statement prior genetic testing

27 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

PRNP was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: UKGTN