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  2. Early onset dementia (encompassing fronto-temporal dementia and prion disease)
  3. TYROBP
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Early onset dementia (encompassing fronto-temporal dementia and prion disease)

Gene: TYROBP

Green List (high evidence)
TYROBP (TYRO protein tyrosine kinase binding protein)
EnsemblGeneIds (GRCh38): ENSG00000011600
EnsemblGeneIds (GRCh37): ENSG00000011600
OMIM: 604142, Gene2Phenotype
TYROBP is in 10 panels

2 reviews

simon mead (UCL)

Green List (high evidence)

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Caroline Wright (Genomics England Curator)

Comment on mode of inheritance: OMIM
Created: 10 May 2016, 2:21 p.m.
Comment on list classification: Associated with Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy in ClinVar and OMIM, which progresses to dementia
Created: 10 May 2016, 2:21 p.m.
Created: 10 May 2016, 2:21 p.m.

Panel version: 0.34

History Filter Activity

10 May 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 May 2016, Gel status: 4

Set publications

Caroline Wright (Genomics England Curator)

Publications for TYROBP were set to 15049507

10 May 2016, Gel status: 4

Set Mode of Inheritance

Caroline Wright (Genomics England Curator)

Mode of inheritance for TYROBP was changed to BIALLELIC, autosomal or pseudoautosomal

10 May 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

27 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

TYROBP was added to Early onset dementia (encompassing fronto-temporal dementia and prion disease)panel. Sources: UKGTN