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Upper gastrointestinal cancer pertinent cancer susceptibility

Gene: MSH6

Green List (high evidence)

MSH6 (mutS homolog 6)
EnsemblGeneIds (GRCh38): ENSG00000116062
EnsemblGeneIds (GRCh37): ENSG00000116062
OMIM: 600678, Gene2Phenotype
MSH6 is in 34 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for Hepatopancreatobiliary/ Upper Gastrointestinal tumour types.
Created: 26 Jul 2017, 12:21 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Adult Glioma; Colorectal; Endometrial Carcinoma; Hepatopancreatobiliary; Ovarian

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Hepatopancreatobiliary
  • Upper Gastrointestinal
OMIM
600678
Clinvar variants
Variants in MSH6
Penetrance
Complete
Panels with this gene

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on list classification

26 Jul 2017, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for MSH6 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

26 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

20 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH6 was added to Upper gastrointestinal cancerpanel. Sources: Expert list

20 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

MSH6 was created by ellenmcdonagh