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Pain syndromes

Gene: NGF

Green List (high evidence)
NGF (nerve growth factor)
EnsemblGeneIds (GRCh38): ENSG00000134259
EnsemblGeneIds (GRCh37): ENSG00000134259
OMIM: 162030, Gene2Phenotype
NGF is in 6 panels

3 reviews

Arianna Tucci (Genomics England Curator)

Green List (high evidence)

Marked as green after internal discussion
Created: 18 Jul 2017, 9:52 a.m.
loss of deep pain and temperature perception. Two families described to date
Created: 29 Jun 2017, 9:24 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Neuropathy, hereditary sensory and autonomic, type V 608654

Created: 18 Jul 2017, 9:52 a.m.

Panel version: 0.63

Louise Daugherty (Genomics England Curator)

I don't know

Comment on phenotypes: reformatted phenotype listing
Created: 19 Sep 2017, 11:34 a.m.
Comment on list classification: changed from Amber to Green after review with clinical team
Created: 18 Jul 2017, 11:19 a.m.
more than five unrelated cases but only two families reported. Amber status but could be confirmed green once review our four main sources. Check with clinical team
Created: 9 Jul 2017, 6:27 p.m.
Comment on list classification: To be reviewed by clinical team regarding the pertinence of this gene
Created: 9 Jul 2017, 5:03 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Neuropathy, hereditary sensory and autonomic, type V; 608654; Congenital sensory neuropathy with selective loss of small myelinated fibers

Created: 9 Jul 2017, 4:30 p.m.

Panel version: 0.3

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Hereditary sensory neuropathy type V (HSAN 5)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 9 Jul 2017, 4:30 p.m.

Panel version: 0.3

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Emory Genetics Laboratory
  • UKGTN
Phenotypes
  • Hereditary sensory neuropathy type V
  • HSAN 5
  • Neuropathy, hereditary sensory and autonomic, type V, 608654
  • Congenital sensory neuropathy with selective loss of small myelinated fibers
OMIM
162030
Clinvar variants
Variants in NGF
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

19 Sep 2017, Gel status: 4

panel promoted to version 1

Louise Daugherty (Genomics England Curator)

19th September 2017. Panel reviews were assessed, and panel was revised according to reviews and further curation.

19 Sep 2017, Gel status: 4

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for NGF were set to Hereditary sensory neuropathy type V;HSAN 5; Neuropathy, hereditary sensory and autonomic, type V, 608654; Congenital sensory neuropathy with selective loss of small myelinated fibers

19 Sep 2017, Gel status: 4

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for NGF were set to Hereditary sensory neuropathy type V (HSAN 5); Neuropathy, hereditary sensory and autonomic, type V, 608654; Congenital sensory neuropathy with selective loss of small myelinated fibers

18 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

11 Jul 2017, Gel status: 2

Upload gene information

Louise Daugherty (Genomics England Curator)

NGF was added to Pain syndromespanel. Sources: UKGTN,Emory Genetics Laboratory

9 Jul 2017, Gel status: 2

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for NGF were set to Hereditary sensory neuropathy type V (HSAN 5);Neuropathy, hereditary sensory and autonomic, type V; 608654; Congenital sensory neuropathy with selective loss of small myelinated fibers

9 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

9 Jul 2017, Gel status: 0

Created

BRIDGE consortium (NIHRBR-RD)

NGF was created by BRIDGE

9 Jul 2017, Gel status: 0

Added New Source

BRIDGE consortium (NIHRBR-RD)

NGF was added to Pain syndromespanel. Sources: BRIDGE Study Tier 1 Gene