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Non-CF bronchiectasis

Gene: DAW1

Green List (high evidence)
DAW1 (dynein assembly factor with WD repeats 1)
EnsemblGeneIds (GRCh38): ENSG00000123977
EnsemblGeneIds (GRCh37): ENSG00000123977
DAW1 is in 5 panels

1 review

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

DAW1 is not in OMIM, Gen2Phen or MONDO. PMID: 36074124 reports five variants in four unrelated cases with a motile ciliopathy / laterality disorder. Helen Brittain (Genomics England, Clinical Fellow) agreed that DAW1 should be green on this panel.
Sources: Literature
Created: 25 Oct 2022, 12:54 p.m. | Last Modified: 25 Oct 2022, 2:26 p.m.
Panel Version: 1.29

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
motile ciliopathy laterality disorder

Publications

Created: 25 Oct 2022, 12:54 p.m.
Last Modified: 25 Oct 2022, 2:26 p.m.
Panel version: 1.28

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Ciliary dyskinesia, primary, 52, OMIM:620570
Tags
gene-checked
Clinvar variants
Variants in DAW1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Oct 2024, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: DAW1 were changed from motile ciliopathy laterality disorder to Ciliary dyskinesia, primary, 52, OMIM:620570

2 Oct 2024, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag gene-checked tag was added to gene: DAW1.

25 Oct 2022, Gel status: 3

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: daw1 has been classified as Green List (High Evidence).

25 Oct 2022, Gel status: 1

Removed Tag, Removed Tag

Sarah Leigh (Genomics England Curator)

Tag Q4_22_MOI was removed from gene: DAW1. Tag Q4_22_promote_green was removed from gene: DAW1.

25 Oct 2022, Gel status: 1

Created, Added New Source, Added Tag, Set mode of inheritance, Set publications, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: DAW1 was added gene: DAW1 was added to Non-CF bronchiectasis. Sources: Literature Q4_22_MOI, Q4_22_promote_green tags were added to gene: DAW1. Mode of inheritance for gene: DAW1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: DAW1 were set to 36074124; 28991257 Phenotypes for gene: DAW1 were set to motile ciliopathy laterality disorder Review for gene: DAW1 was set to GREEN