Non-CF bronchiectasis

Gene: DNAI1

Red List (low evidence)

DNAI1 (dynein axonemal intermediate chain 1)
EnsemblGeneIds (GRCh38): ENSG00000122735
EnsemblGeneIds (GRCh37): ENSG00000122735
OMIM: 604366, Gene2Phenotype
DNAI1 is in 12 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Associated with Ciliary dyskinesia, primary, and is green on the Primary Ciliary dyskinesia gene panel. Should remain red for this panel.
Created: 10 May 2016, 8:24 a.m.

Anthony De Soyza (NEWCASTLE university/ freeman hospital bronchiectasis service)

Green List (high evidence)

Important to exclude the known PCD variants in suspected idiopathic bronchiectasis
Created: 17 Oct 2015, 7:23 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
PCD phenotypes

Publications

History Filter Activity

10 May 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

10 May 2016, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for DNAI1 were set to Bronchiectasis; Ciliary dyskinesia, primary, 1, with or without situs inversus

10 May 2016, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for DNAI1 were set to PMID: 18950741

10 May 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

DNAI1 was added to Non-CF bronchiectasispanel. Sources: Emory Genetics Laboratory