1. Panels
  2. Non-CF bronchiectasis
  3. DNAH5
STRs in panel
Prev Next
Regions in panel
Prev Next

Non-CF bronchiectasis

Gene: DNAH5

Green List (high evidence)
DNAH5 (dynein axonemal heavy chain 5)
EnsemblGeneIds (GRCh38): ENSG00000039139
EnsemblGeneIds (GRCh37): ENSG00000039139
OMIM: 603335, Gene2Phenotype
DNAH5 is in 12 panels

3 reviews

Ivone Leong (Genomics England Curator)

Comment on list classification: Promoted from Red to Green based on expert review from Zerin Hyder (Genomics England).
Created: 5 Oct 2020, 2:16 p.m. | Last Modified: 5 Oct 2020, 2:16 p.m.
Panel Version: 1.26
Created: 5 Oct 2020, 2:16 p.m.
Last Modified: 5 Oct 2020, 2:16 p.m.
Panel version: 1.26

Zerin Hyder (Genomics England)

Green List (high evidence)

Sufficient cases for causation for PCD +/- laterality. Current evidence for structural cardiac involvement is from a mouse model (see listed PMID).
Created: 10 Jul 2020, 8:36 a.m. | Last Modified: 10 Jul 2020, 8:36 a.m.
Panel Version: 1.22

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Primary Ciliary Dyskinesia; Ciliary dyskinesia, primary, 3, with or without situs inversus, 608644; situs inversus

Publications

Created: 10 Jul 2020, 8:36 a.m.
Last Modified: 10 Jul 2020, 8:36 a.m.
Panel version: 1.22

Anthony De Soyza (NEWCASTLE university/ freeman hospital bronchiectasis service)

Red List (low evidence)

should be considered if PCD suspected
Created: 31 Mar 2016, 6:32 p.m.

Mode of inheritance
Unknown

Created: 31 Mar 2016, 6:32 p.m.

Panel version: 0.0

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Emory Genetics Laboratory
Phenotypes
  • Bronchiectasis
  • Primary Ciliary Dyskinesia
  • Ciliary dyskinesia, primary, 3, with or without situs inversus, 608644
  • situs inversus
OMIM
603335
Clinvar variants
Variants in DNAH5
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

5 Oct 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: dnah5 has been classified as Green List (High Evidence).

5 Oct 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: DNAH5 were set to

5 Oct 2020, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: DNAH5 were changed from Bronchiectasis to Bronchiectasis; Primary Ciliary Dyskinesia; Ciliary dyskinesia, primary, 3, with or without situs inversus, 608644; situs inversus

5 Oct 2020, Gel status: 1

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: DNAH5 was changed from to BIALLELIC, autosomal or pseudoautosomal

20 May 2020, Gel status: 1

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: dnah5 has been classified as Red List (Low Evidence).

20 May 2020, Gel status: 3

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: dnah5 has been classified as Green List (High Evidence).

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

DNAH5 was added to Non-CF bronchiectasispanel. Sources: Emory Genetics Laboratory