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  3. WNT10B
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Limb disorders

Gene: WNT10B

Green List (high evidence)
WNT10B (Wnt family member 10B)
EnsemblGeneIds (GRCh38): ENSG00000169884
EnsemblGeneIds (GRCh37): ENSG00000169884
OMIM: 601906, Gene2Phenotype
WNT10B is in 5 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM and G2P. At least three variants reported
Created: 1 Aug 2016, 9:46 a.m.
Created: 1 Aug 2016, 9:46 a.m.

Panel version: Imported from Unexplained skeletal dysplasia panel version 0.1225

Ana Beleza (Bristol Regional Genetics Service)

Green List (high evidence)

Tier 2
Created: 17 Jun 2016, 8:09 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Split-hand/foot malformation 6 225300

Variants in this GENE are reported as part of current diagnostic practice

Created: 17 Jun 2016, 8:09 a.m.

Panel version: Imported from Unexplained skeletal dysplasia panel version 0.4

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert list
  • Radboud University Medical Center, Nijmegen
  • Expert Review Green
  • London South East RGC GSTT
  • Viapath
Phenotypes
  • Split-hand/foot malformation 6, OMIM:225300
OMIM
601906
Clinvar variants
Variants in WNT10B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

22 Jul 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: WNT10B were changed from Split-hand/foot malformation 6 225300 to Split-hand/foot malformation 6, OMIM:225300

11 Dec 2018, Gel status: 4

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

Ana Beleza: Tier 2

5 Apr 2018, Gel status: 4

Added New Source, Added New Source, Added New Source, Set mode of inheritance, Set publications

Ellen McDonagh (Genomics England Curator)

Expert Review Green was added to WNT10B. Panel: Limb disorders Radboud University Medical Center, Nijmegen was added to WNT10B. Panel: Limb disorders Expert list was added to WNT10B. Panel: Limb disorders Model of inheritance for gene WNT10B was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene WNT10B was set to ['24211389']

27 Nov 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

London South East RGC GSTT was added to WNT10B. Panel: Limb disorders

17 Nov 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

WNT10B was added to Limb disorders panel. Sources: Viapath

17 Nov 2017, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

WNT10B was created by Ellen McDonagh