Limb disorders
Gene: ZNF141Genomics England clinical team notes - Agree with red rating. Single report in one family/.Created: 9 Sep 2018, 7:56 p.m.
PMID: 23160277 - family report of a missense variant segregating with autosomal recessive postaxial polydactyly type A. Functional analysis was not carried out to confirm the effect of the missense. Not enough evidence at this time for this gene to be green - added the watchlist tag.Created: 7 Nov 2018, 1:26 p.m.
Comment on publications: PMID: one family described with a homozygous missense variant in this gene segregating with postaxial polydactyly type A.Created: 9 Apr 2018, 2:41 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
?Polydactyly, postaxial, type A6 615226; Polydactyly
Publications
Ellen McDonagh: Comment on publications: PMID:
Gene: znf141 has been classified as Red List (Low Evidence).
Tag watchlist tag was added to gene: ZNF141.
Source Expert Review Red was added to ZNF141. Added phenotypes ?Polydactyly, postaxial, type A6 615226; Polydactyly for gene: ZNF141
Victorian Clinical Genetics Services was added to ZNF141. Panel: Limb disorders Phenotypes for gene ZNF141 were set to ?Polydactyly, postaxial, type A6 615226, Polydactyly
Publications for ZNF141 were set to 23160277
Publications for ZNF141 were set to 23160277
ZNF141 was added to Limb disorders panel. Sources: Other
ZNF141 was created by Ellen McDonagh