Pancreatitis

Gene: PRSS2

Ensembl identifier not available for GRCh37 (release 82)

Created: 8 Jul 2020, 2:04 p.m. | Last Modified: 8 Jul 2020, 2:04 p.m.

Panel Version: 2.4

I don't know

Initial gene list and info collated by Miranda Durkie Sheffield Diagnostic Genetics Service December 2018 on behalf of the GMS Gastrohepatology specialist test group. Gene Symbol submitted: PRSS2; Suggested intial gene rating: Amber; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given

Created: 7 Jan 2019, 4:15 p.m.

Red List (low evidence)

Could not find evidence for an association with inherited pancreatitis.

Created: 6 Dec 2018, 1:16 p.m.

Comment on publications: PMID: 16699518 - the G191R variant in this gene is deemed protective against chronic pancreatitis.

Created: 6 Dec 2018, 1:10 p.m.

Comment on publications: PMID: 14695529 - a mutation in PRSS1 causes increased transactivation of PRSS2.

Created: 6 Dec 2018, 1:09 p.m.

Comment on publications: Multiple association studies for PRSS1-PRSS2 locus and chronic pancreatitis, tropical calfific pancreatitis, acute pancreatitis, alcoholic and non-alcoholic pancreatitis, sporadic pancreatitis.

Created: 6 Dec 2018, 1:07 p.m.