Pancreatitis

Gene: CCL2

Red List (low evidence)

CCL2 (C-C motif chemokine ligand 2)
EnsemblGeneIds (GRCh38): ENSG00000108691
EnsemblGeneIds (GRCh37): ENSG00000108691
OMIM: 158105, Gene2Phenotype
CCL2 is in 5 panels

1 review

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

Comment on publications: PMID: 23449669 - CCL2 knockout exacerbates chronic pancreatitis.
Created: 6 Dec 2018, 1:20 p.m.
This is a chemokine involved in inflammation and pancreatitis pathology, however there does not seem to be enough evidence in the published literature at this time for variants in this gene to be causative of pancreatitis. Not associated with pancreatitis in OMIM for reported cases. PMID: 25499426 - meta-analysis found an association with a polymorphism in this gene and pancreatitis risk.
Created: 6 Dec 2018, 12:17 p.m.

History Filter Activity

10 Dec 2018, Gel status: 1

Panel promoted to version 1.0

Ellen McDonagh (Genomics England Curator)

Ellen McDonagh: This is a chemokine involved i

6 Dec 2018, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for gene: CCL2 were set to

2 May 2018, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

CCL2 was added to Pancreatitis panel. Sources: EUROPAC

2 May 2018, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

CCL2 was created by Ellen McDonagh