Pancreatitis
Gene: PRSS2Ensembl identifier not available for GRCh37 (release 82)Created: 8 Jul 2020, 2:04 p.m. | Last Modified: 8 Jul 2020, 2:04 p.m.
Panel Version: 2.4
Initial gene list and info collated by Miranda Durkie Sheffield Diagnostic Genetics Service December 2018 on behalf of the GMS Gastrohepatology specialist test group. Gene Symbol submitted: PRSS2; Suggested intial gene rating: Amber; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none givenCreated: 7 Jan 2019, 4:15 p.m.
Could not find evidence for an association with inherited pancreatitis.Created: 6 Dec 2018, 1:16 p.m.
Comment on publications: PMID: 16699518 - the G191R variant in this gene is deemed protective against chronic pancreatitis.Created: 6 Dec 2018, 1:10 p.m.
Comment on publications: PMID: 14695529 - a mutation in PRSS1 causes increased transactivation of PRSS2.Created: 6 Dec 2018, 1:09 p.m.
Comment on publications: Multiple association studies for PRSS1-PRSS2 locus and chronic pancreatitis, tropical calfific pancreatitis, acute pancreatitis, alcoholic and non-alcoholic pancreatitis, sporadic pancreatitis.Created: 6 Dec 2018, 1:07 p.m.
Tag ensembl_ids_known_missing tag was added to gene: PRSS2.
Source NHS GMS was added to PRSS2.
Ellen McDonagh: Comment on publications: Multi
Publications for gene: PRSS2 were set to 25253127; 23143602; 27846138; 26784911; 26002935; 26110235; 29884332; 19052022; 15776435; 16699518; 14695529
Phenotypes for gene: PRSS2 were changed from to {Pancreatitis, chronic, protection against} 167800
Publications for gene: PRSS2 were set to 25253127; 23143602; 27846138; 26784911; 26002935; 26110235; 29884332; 19052022; 15776435; 16699518; 18362849; 14695529
Publications for gene: PRSS2 were set to 25253127; 23143602; 27846138; 26784911; 26002935; 26110235; 29884332; 19052022; 15776435; 16699518
Publications for gene: PRSS2 were set to
PRSS2 was added to Pancreatitis panel. Sources: EUROPAC
PRSS2 was created by Ellen McDonagh