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Cardiac arrhythmias - previous panel

Gene: KCNH2

Green List (high evidence)
KCNH2 (potassium voltage-gated channel subfamily H member 2)
EnsemblGeneIds (GRCh38): ENSG00000055118
EnsemblGeneIds (GRCh37): ENSG00000055118
OMIM: 152427, Gene2Phenotype
KCNH2 is in 5 panels

0 reviews

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
Phenotypes
  • Brugada
  • Long QT syndrome 2 613688
  • cardiac arrest
  • ventricular fibrillation
  • Brugada/Brugada like syndrome
  • Long QT syndrome-2
  • short qt
  • Short QT syndrome 1 609620
  • atrial fibrillation
OMIM
152427
Clinvar variants
Variants in KCNH2
Penetrance
None
Publications
Mode of Pathogenicity
Other - please provide details in the comments
Panels with this gene

History Filter Activity

28 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Ellen McDonagh (Genomics England Curator)

Checked against the component panels, and ready to be promoted to version 1.

17 Dec 2018, Gel status: 4

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Added phenotypes Brugada/Brugada like syndrome; Short QT syndrome 1 609620; Long QT syndrome 2 613688 for gene: KCNH2

17 Dec 2018, Gel status: 4

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Added phenotypes Long QT syndrome-2 for gene: KCNH2

17 Dec 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Rebecca Foulger (Genomics England curator)

gene: KCNH2 was added gene: KCNH2 was added to Cardiac arrythmias. Sources: Expert Review Green Mode of inheritance for gene: KCNH2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: KCNH2 were set to 16043162; 19439805; 14676148; 18692916; 21130771; 16039272; 19174314; 16011830; 19340359; 29085299; 25974115; 22194679; 29016797; 15828882; 29759541 Phenotypes for gene: KCNH2 were set to Brugada; cardiac arrest; ventricular fibrillation; short qt; Short QT syndrome 1 609620; atrial fibrillation Mode of pathogenicity for gene: KCNH2 was set to Other - please provide details in the comments