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Cardiac arrhythmias - previous panel

Gene: ALG10

Red List (low evidence)
ALG10 (ALG10, alpha-1,2-glucosyltransferase)
EnsemblGeneIds (GRCh38): ENSG00000139133
EnsemblGeneIds (GRCh37): ENSG00000139133
OMIM: 603313, Gene2Phenotype
ALG10 is in 3 panels

1 review

Sarah Leigh (Genomics England Curator)

ALG10 OMIM:618355 is not associated with cardiac arrhythmias in OMIM or Gen2Phen. However, ALG10B OMIM:603313 is associated with Long QT syndrome, acquired, reduced susceptibility to OMIM:613688 (PMID:15280551). ALG10 was added to this panel in error.
Created: 28 Oct 2021, 10:26 a.m. | Last Modified: 28 Oct 2021, 2:09 p.m.
Panel Version: 1.5
Created: 28 Oct 2021, 10:19 a.m.
Last Modified: 28 Oct 2021, 2:09 p.m.
Panel version: 1.4

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
Phenotypes
  • Progressive myoclonus epilepsy
  • CDG
OMIM
603313
Clinvar variants
Variants in ALG10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 Oct 2021, Gel status: 1

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for gene: ALG10 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BIALLELIC, autosomal or pseudoautosomal

28 Oct 2021, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: ALG10 were set to

28 Oct 2021, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: ALG10 were changed from {Acquired long QT syndrome, reduced susceptibility to}, 613688; {Long QT syndrome, acquired, reduced susceptibility to} 613688 to Progressive myoclonus epilepsy; CDG

28 Oct 2021, Gel status: 1

Removed Tag

Sarah Leigh (Genomics England Curator)

Tag new-gene-name was removed from gene: ALG10.

26 Oct 2021, Gel status: 1

Added Tag

Sarah Leigh (Genomics England Curator)

Tag new-gene-name tag was added to gene: ALG10.

28 Jan 2019, Gel status: 1

Panel promoted to version 1.0

Ellen McDonagh (Genomics England Curator)

Eleanor Williams: Sources: Literature

17 Dec 2018, Gel status: 1

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Added phenotypes {Long QT syndrome, acquired, reduced susceptibility to} 613688 for gene: ALG10

17 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: ALG10 was added gene: ALG10 was added to Cardiac arrythmias. Sources: Expert Review Red Mode of inheritance for gene: ALG10 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: ALG10 were set to {Acquired long QT syndrome, reduced susceptibility to}, 613688