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  2. Dilated Cardiomyopathy and conduction defects
  3. FHL2
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Dilated Cardiomyopathy and conduction defects

Gene: FHL2

Red List (low evidence)
FHL2 (four and a half LIM domains 2)
EnsemblGeneIds (GRCh38): ENSG00000115641
EnsemblGeneIds (GRCh37): ENSG00000115641
OMIM: 602633, Gene2Phenotype
FHL2 is in 1 panel

2 reviews

Rebecca Whittington (South West GLH)

Red List (low evidence)

Phenotype not listed on OMIM
Created: 25 Mar 2019, 4:30 p.m.
HGMD Only two variants assoc with DCM - both know freq but classed as 3 in Walsh 2017 and Dal Ferro 2017. Also only 2 DM variants assoc with HCM - but some functional studies show downregulation of this gene in HCM: Friedrich (2014) Basic Res Cardiol 109: 451 PubMed: 25358972 FHL2 expression and variants in hypertrophic cardiomyopathy.
Created: 25 Mar 2019, 4:27 p.m.

Variants in this GENE are reported as part of current diagnostic practice

Created: 25 Mar 2019, 4:24 p.m.

Panel version: 1.55

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

Red List (low evidence)

Created: 6 Jan 2016, 5:12 p.m.

Panel version: 0.0

Details

Sources
  • South West GLH
  • Expert list
OMIM
602633
Clinvar variants
Variants in FHL2
Penetrance
Complete
Panels with this gene

History Filter Activity

21 Feb 2019, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

Source South West GLH was added to FHL2.

14 Jul 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

FHL2 was added to Dilated Cardiomyopathy and conduction defectspanel. Sources: Expert list