Dilated Cardiomyopathy and conduction defects

Gene: TAZ

Green List (high evidence)

TAZ (tafazzin)
EnsemblGeneIds (GRCh38): ENSG00000102125
EnsemblGeneIds (GRCh37): ENSG00000102125
OMIM: 300394, Gene2Phenotype
TAZ is in 20 panels

4 reviews

Arina Puzriakova (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol for TAZ is TAFAZZIN
Created: 10 May 2022, 3:27 p.m. | Last Modified: 10 May 2022, 3:27 p.m.
Panel Version: 1.77

Rebecca Whittington (South West GLH)

I don't know

Barth syndrome OMIM#302060
Created: 25 Mar 2019, 4:30 p.m.
Paediatric onset disease. Included in review of DCM genes: Dalin 2017 International Journal of Cardiology 228 (2017) 742748, Hershberger 2013 Nat Rev Cardiol 10:531 and Pugh (2014) Genet Med 16, 601.
Created: 25 Mar 2019, 4:27 p.m.
Paediatric onset only - paediatric panel. To date only one TAZ variant detected through panel testing. All other positive from targeted TAZ gene testing.
Created: 25 Mar 2019, 4:24 p.m.

Mode of inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Variants in this GENE are reported as part of current diagnostic practice

Caroline Wright (Genomics England Curator)

Comment when marking as ready: Barth syndrome on DDG2P
Created: 14 Feb 2016, 4:22 p.m.

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

Green List (high evidence)

History Filter Activity

10 May 2022, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag new-gene-name tag was added to gene: TAZ.

21 Feb 2019, Gel status: 3

Added New Source, Set mode of inheritance, Status Update

Ellen McDonagh (Genomics England Curator)

Source South West GLH was added to TAZ. Mode of inheritance for gene TAZ was changed from X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) to X-LINKED: hemizygous mutation in males, biallelic mutations in females Rating Changed from Green List (high evidence) to Green List (high evidence)

14 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

14 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

14 Jul 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene TAZ was changed to X-LINKED: hemizygous mutation in males, may be caused by monoallelic mutations in females

14 Jul 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

TAZ was added to Dilated Cardiomyopathy and conduction defectspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services

14 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

TAZ was added to Dilated Cardiomyopathy and conduction defectspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services