Dilated Cardiomyopathy and conduction defects
Gene: HFE
Hemochromatosis OMIM:235200; {HFE hemochromatosis, modifier of} OMIM#235200Created: 25 Mar 2019, 4:30 p.m.
Adult onset haemochromatosis.Created: 25 Mar 2019, 4:27 p.m.
Is haemochromatosis relevant on this panel?Created: 25 Mar 2019, 4:24 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Variants in this GENE are reported as part of current diagnostic practice
Comment on list classification: Promotion of this gene from red to green on this panel is appropriate, based on the review in the Undiagnosed metabolic disorders panel and the views of clinical expert, Dr Arianna Tucci, UCL.Created: 20 Mar 2017, 11:52 a.m.
Not fully reviewed however doesn't appear to be associated with primary non-syndromic teen/adult onset DCM.Created: 17 Jan 2019, 5:41 p.m.
Source South West GLH was added to HFE.
Source Wessex and West Midlands GLH was added to HFE. Rating Changed from Green List (high evidence) to Green List (high evidence)
Phenotypes for HFE were set to Hemochromatosis 235200
Mode of inheritance for HFE was changed to BIALLELIC, autosomal or pseudoautosomal
This gene has been classified as Green List (High Evidence).
HFE was added to Dilated Cardiomyopathy and conduction defectspanel. Sources: Expert list