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DDG2P

Gene: ADAMTS15

Green List (high evidence)
ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15)
EnsemblGeneIds (GRCh38): ENSG00000166106
EnsemblGeneIds (GRCh37): ENSG00000166106
OMIM: 607509, Gene2Phenotype
ADAMTS15 is in 3 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for ADAMTS15-related distal arthrogryposis are moderate, biallelic_autosomal and undetermined (PMID:35962790). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03420.
Created: 13 Feb 2026, 9:26 p.m. | Last Modified: 13 Feb 2026, 9:26 p.m.
Panel Version: 6.17

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ADAMTS15-related distal arthrogryposis; OMIM:620545.0; MONDO:0957819

Publications

Created: 13 Feb 2026, 9:26 p.m.
Last Modified: 13 Feb 2026, 9:26 p.m.
Panel version: 6.17

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • DD-Gene2Phenotype
  • Expert Review Green
Phenotypes
  • MONDO:0957819
  • ADAMTS15-related distal arthrogryposis
  • OMIM:620545.0
OMIM
607509
Clinvar variants
Variants in ADAMTS15
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Feb 2026, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: ADAMTS15 was added gene: ADAMTS15 was added to DDG2P. Sources: Expert Review Green,DD-Gene2Phenotype Mode of inheritance for gene: ADAMTS15 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ADAMTS15 were set to 35962790 Phenotypes for gene: ADAMTS15 were set to MONDO:0957819; ADAMTS15-related distal arthrogryposis; OMIM:620545.0