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DDG2P

Gene: WT1

Green List (high evidence)

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 21 panels

1 review

Rebecca Foulger (Genomics England curator)

I don't know

Original DDG2P rating: confirmed (for all listed disorders). DDG2P mode of pathogenicity for both disorders: dominant negative
Created: 19 Nov 2018, 11:31 a.m.

History Filter Activity

29 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Rebecca Foulger (Genomics England curator)

Rebecca Foulger: Original DDG2P rating: confirm

19 Nov 2018, Gel status: 4

Set Phenotypes, Set publications

Rebecca Foulger (Genomics England curator)

Added phenotypes FRASIER SYNDROME FRASIER SYNDROME FRASIER SYNDROME 136680 for gene: WT1 Publications for gene WT1 were changed from 8388765; 1655284; 1302008; 1327525 to 1658787; 9499425; 10571943

19 Nov 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Rebecca Foulger (Genomics England curator)

gene: WT1 was added gene: WT1 was added to DDG2P. Sources: Expert Review Green,DD-Gene2Phenotype Mode of inheritance for gene: WT1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: WT1 were set to 8388765; 1655284; 1302008; 1327525 Phenotypes for gene: WT1 were set to DENYS-DRASH SYNDROME 194080 Mode of pathogenicity for gene: WT1 was set to Other - please provide details in the comments