DDG2P
Gene: SLIT3

SLIT3 (slit guidance ligand 3)
EnsemblGeneIds (GRCh38): ENSG00000184347
EnsemblGeneIds (GRCh37): ENSG00000184347
OMIM: 603745, Gene2Phenotype
SLIT3 is in 1 panel

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for SLIT3-related congenital anomalies are limited, biallelic_autosomal and loss of function (PMIDs: 29100090, 33933663). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03748.
Created: 13 Feb 2026, 9:26 p.m. | Last Modified: 13 Feb 2026, 9:26 p.m.

Panel Version: 6.17

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
SLIT3-related congenital anomalies

Publications

Created: 13 Feb 2026, 9:26 p.m.
Last Modified: 13 Feb 2026, 9:26 p.m.
Panel version: 6.17

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

DD-Gene2Phenotype
Expert Review Red

Phenotypes

SLIT3-related congenital anomalies

OMIM

603745

Clinvar variants

Variants in SLIT3

Penetrance

None

Publications

Panels with this gene

DDG2P

History Filter Activity

13 Feb 2026, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: SLIT3 was added gene: SLIT3 was added to DDG2P. Sources: Expert Review Red,DD-Gene2Phenotype Mode of inheritance for gene: SLIT3 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: SLIT3 were set to 33933663; 29100090 Phenotypes for gene: SLIT3 were set to SLIT3-related congenital anomalies

DDG2P Gene: SLIT3