DDG2P
Gene: ZNF335

ZNF335 (zinc finger protein 335)
EnsemblGeneIds (GRCh38): ENSG00000198026
EnsemblGeneIds (GRCh37): ENSG00000198026
OMIM: 610827, Gene2Phenotype
ZNF335 is in 6 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for ZNF335-related microcephaly, epilepsy, cerebral and/or cerebellar atrophy and short stature are strong, biallelic_autosomal and loss of function (PMIDs: 23178126, 27540107, 29652087, 31187448, 33216650, 34982360, 38549403, 40583037). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03774.
Created: 13 Feb 2026, 9:26 p.m. | Last Modified: 13 Feb 2026, 9:26 p.m.

Panel Version: 6.17

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
OMIM:615095.0; MONDO:0014043; ZNF335-related microcephaly, epilepsy, cerebral and/or cerebellar atrophy and short stature

Publications

Created: 13 Feb 2026, 9:26 p.m.
Last Modified: 13 Feb 2026, 9:26 p.m.
Panel version: 6.17

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

DD-Gene2Phenotype
Expert Review Green

Phenotypes

MONDO:0014043
ZNF335-related microcephaly, epilepsy, cerebral and/or cerebellar atrophy and short stature
OMIM:615095.0

OMIM

610827

Clinvar variants

Variants in ZNF335

Penetrance

None

Publications

Panels with this gene

History Filter Activity

13 Feb 2026, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: ZNF335 was added gene: ZNF335 was added to DDG2P. Sources: Expert Review Green,DD-Gene2Phenotype Mode of inheritance for gene: ZNF335 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ZNF335 were set to 38549403; 27540107; 29652087; 23178126; 40583037; 33216650; 34982360; 31187448 Phenotypes for gene: ZNF335 were set to MONDO:0014043; ZNF335-related microcephaly, epilepsy, cerebral and/or cerebellar atrophy and short stature; OMIM:615095.0

DDG2P Gene: ZNF335