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DDG2P

Gene: ZNF407

Red List (low evidence)
ZNF407 (zinc finger protein 407)
EnsemblGeneIds (GRCh38): ENSG00000215421
EnsemblGeneIds (GRCh37): ENSG00000215421
OMIM: 615894, Gene2Phenotype
ZNF407 is in 2 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for ZNF407-related neurodevelopmental disorder are limited, biallelic_autosomal and undetermined (PMIDs: 24907849, 32737394). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03027.
Created: 13 Feb 2026, 9:26 p.m. | Last Modified: 13 Feb 2026, 9:26 p.m.
Panel Version: 6.17
The DDG2P confidence category for the disease ZNF407-related Neurodevelopmental Disorder is limited. The allelic requirement and mutation consequence are biallelic_autosomal and altered gene product structure (PMIDs: 32737394;24907849).
Created: 4 Oct 2023, 5:08 p.m. | Last Modified: 4 Oct 2023, 5:08 p.m.
Panel Version: 3.12

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ZNF407-related Neurodevelopmental Disorder; OMIM:619557.0; MONDO:0859198; ZNF407-related neurodevelopmental disorder

Publications

Mode of pathogenicity
Other

Created: 4 Oct 2023, 5:08 p.m.
Last Modified: 4 Oct 2023, 5:08 p.m.
Panel version: 6.17

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • DD-Gene2Phenotype
Phenotypes
  • ZNF407-related Neurodevelopmental Disorder
OMIM
615894
Clinvar variants
Variants in ZNF407
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Feb 2026, Gel status: 1

Set mode of pathogenicity

Achchuthan Shanmugasundram (Genomics England Curator)

Mode of pathogenicity for gene: ZNF407 was changed from Other to None

4 Oct 2023, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Achchuthan Shanmugasundram (Genomics England Curator)

gene: ZNF407 was added gene: ZNF407 was added to DDG2P. Sources: DD-Gene2Phenotype,Expert Review Red Mode of inheritance for gene: ZNF407 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ZNF407 were set to 24907849; 32737394 Phenotypes for gene: ZNF407 were set to ZNF407-related Neurodevelopmental Disorder Mode of pathogenicity for gene: ZNF407 was set to Other