1. Panels
  2. Renal and urinary tract disorders
  3. NEK8
STRs in panel
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Renal and urinary tract disorders

Gene: NEK8

Red List (low evidence)
NEK8 (NIMA related kinase 8)
EnsemblGeneIds (GRCh38): ENSG00000160602
EnsemblGeneIds (GRCh37): ENSG00000160602
OMIM: 609799, Gene2Phenotype
NEK8 is in 13 panels

3 reviews

Ellen Thomas (Genomics England Curator)

Comment on list classification: Only 1 family. Await further evidence.
Created: 10 May 2016, 10:48 a.m.
Created: 10 May 2016, 10:48 a.m.

Panel version: Imported from Cystic kidney disease panel version 0.33

Miranda Durkie (Genetics)

Green List (high evidence)

No current test experience but this gene is on the list for an extended panel.
Created: 22 Oct 2015, 12:02 p.m.
Created: 22 Oct 2015, 12:02 p.m.

Panel version: Imported from Cystic kidney disease panel version 0

Helen Stuart (University of Manchester)

Red List (low evidence)

Rare, not a CAKUT gene pe se.
Created: 18 Oct 2015, 8:47 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 18 Oct 2015, 8:47 p.m.

Panel version: Imported from CAKUT panel version 0

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
Phenotypes
  • Ciliopathy genes associated with cystic kidney disease
  • ?Nephronophthisis 9, 613824?Renal-hepatic-pancreatic dysplasia 2, 615415
OMIM
609799
Clinvar variants
Variants in NEK8
Penetrance
None
Panels with this gene

History Filter Activity

30 Jan 2019, Gel status: 1

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

Helen Stuart: Rare, not a CAKUT gene pe se.

20 Dec 2018, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Added phenotypes Ciliopathy genes associated with cystic kidney disease for gene: NEK8

20 Dec 2018, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Added phenotypes Ciliopathy genes associated with cystic kidney disease; ?Nephronophthisis 9, 613824?Renal-hepatic-pancreatic dysplasia 2, 615415 for gene: NEK8

20 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: NEK8 was added gene: NEK8 was added to Renal and urinary tract disorders. Sources: Expert Review Red Mode of inheritance for gene: NEK8 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: NEK8 were set to ?Nephronophthisis 9, 613824?Renal-hepatic-pancreatic dysplasia 2, 615415