Renal and urinary tract disorders
Gene: WT1

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM and G2P. At least five variants reported
Created: 5 Aug 2016, 1:17 p.m.

Comment on phenotypes: Also associated with Denys-Drash syndrome 194080, Frasier syndrome 136680, Meacham syndrome 608978, Mesothelioma, somatic 156240; Wilms tumor, type 1 194070
Created: 5 Aug 2016, 1:16 p.m.

Comment on list classification: Promoted from Red to Green because this gene is Green in Version 1 of the Proteinuric renal disease gene panel
Created: 17 Jun 2016, 9:29 a.m.

Created: 17 Jun 2016, 9:29 a.m.

Panel version: Imported from End-stage renal disease - childhood onset panel version 0.33

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green

Phenotypes

Nephrotic syndrome, type 4 256370

OMIM

607102

Clinvar variants

Variants in WT1

Penetrance

None

Panels with this gene

History Filter Activity

30 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

Sarah Leigh: Comment on list classification

30 Jan 2019, Gel status: 4

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: WT1 were changed from Nephrotic syndrome, type 4 to Nephrotic syndrome, type 4 256370

20 Dec 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: WT1 was added gene: WT1 was added to Renal and urinary tract disorders. Sources: Expert Review Green Mode of inheritance for gene: WT1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: WT1 were set to Nephrotic syndrome, type 4

Renal and urinary tract disorders Gene: WT1