Inherited polyposisGene: MSH3
Comment on phenotypes: This gene is also associated with Endometrial carcinoma, somatic (MIM# 608089)
Created: 8 Mar 2021, 11:01 a.m. | Last Modified: 8 Mar 2021, 11:01 a.m.
Panel Version: 1.21
Comment on mode of inheritance: Corrected the MOI. Changed Monoallelic to Biallelic.
Created: 5 Aug 2019, 10:21 a.m. | Last Modified: 5 Aug 2019, 10:21 a.m.
Panel Version: 0.51
Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber as cases in this gene is rare.
Created: 1 Feb 2019, 10:06 a.m.
Discussed with Prof Ian Tomlinson. To be added to PanelApp as there has been a recent proposal that it may be asssociated with autosomal recessive polyposis/CRC. Not yet published hence low evidence.
Created: 20 Jul 2016, 7:09 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Publications for gene: MSH3 were set to
Phenotypes for gene: MSH3 were changed from to Familial adenomatous polyposis 4, OMIM:617100
Mode of inheritance for gene: MSH3 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BIALLELIC, autosomal or pseudoautosomal
Gene: msh3 has been classified as Amber List (Moderate Evidence).
Mode of inheritance for gene: MSH3 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: msh3 has been classified as Green List (High Evidence).
gene: MSH3 was added gene: MSH3 was added to Inherited polyposis. Sources: NHS GMS Mode of inheritance for gene: MSH3 was set to