Inherited polyposis and early onset colorectal cancer - germline testing
Gene: MUTYHComment on phenotypes: This gene is also associated with Gastric cancer, somatic (MIM# 613659)Created: 8 Mar 2021, 10:11 a.m. | Last Modified: 8 Mar 2021, 10:11 a.m.
Panel Version: 1.12
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:34 p.m. | Last Modified: 31 Jul 2019, 12:34 p.m.
Panel Version: 0.48
Publications
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Tumor Suppressor.Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Colorectal cancer
Comment on list classification: Current diagnostic.Created: 7 Feb 2016, 9:25 p.m.
http://chromium.lovd.nl/LOVD2/colon_cancer/home.php?select_db=MUTYH
Created: 8 Dec 2015, 2:24 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Publications
Phenotypes for gene: MUTYH were changed from Gastrointestinal and Colorectal Cancer High Risk Adenomas, multiple colorectal 608456 to Adenomas, multiple colorectal, OMIM:608456
Added phenotypes Gastrointestinal and Colorectal Cancer High Risk Adenomas, multiple colorectal 608456 for gene: MUTYH
Mode of inheritance for gene: MUTYH was changed from to BIALLELIC, autosomal or pseudoautosomal
Gene: mutyh has been classified as Green List (High Evidence).
gene: MUTYH was added gene: MUTYH was added to Inherited polyposis. Sources: Expert List,NHS GMS Mode of inheritance for gene: MUTYH was set to