MUTYH

mutY DNA glycosylase
OMIM: 604933, Gene2Phenotype

11 panels

Panel Reviews Mode of inheritance Details
11 panels

Red MUTYH in Familial breast cancer

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.14

review Not set
Sources
  • Emory Genetics Laboratory
Phenotypes
  • Breast and Ovarian Cancer

Green MUTYH in Additional findings health related


Version 0.110

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Other
  • Expert Review Green
Phenotypes
  • Bowel cancer predisposition
  • MYH-associated polyposis
  • Adult only
Tags
  • adult-onset

Green MUTYH in Colorectal cancer pertinent cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.0

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Colorectal cancer

Green MUTYH in Adult solid tumours for rare disease

Level 3: Tumour syndromes
Level 2: Tumour syndromes
Version 1.25

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review Green
Phenotypes
  • Colorectal cancer

Red MUTYH in Inherited ovarian cancer (without breast cancer)

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 2.21
Latest signed off version: v2.2 (4 Mar 2020)

review Not set
Sources
  • Emory Genetics Laboratory
Phenotypes
  • Breast and Ovarian Cancer

Green MUTYH in GI tract tumours

Level 3: GI tract
Level 2: Tumour syndromes
Version 1.18

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert List
  • Illumina TruGenome Clinical Sequencing Services
  • UKGTN
  • Eligibility statement prior genetic testing
  • Emory Genetics Laboratory
  • Expert Review Green
  • Expert list
Phenotypes
  • Gastrointestinal and Colorectal Cancer High Risk Adenomas, multiple colorectal 608456

Green MUTYH in Inherited polyposis


Version 1.24
Latest signed off version: v1.2 (4 Mar 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
  • Expert List
Phenotypes
  • Adenomas, multiple colorectal, OMIM:608456

Green MUTYH in Adult solid tumours cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 2.14
Latest signed off version: v2.2 (18 Feb 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Green
  • Expert list
Phenotypes
  • Colorectal cancer

Red MUTYH in Severe Paediatric Disorders


Version 1.81

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Next Generation Children Project
  • Expert Review Red
  • Expert list
Phenotypes
  • Angiofibroma, somatic
  • Carcinoid tumor of lung
  • Multiple endocrine neoplasia 1, 131100
  • Lipoma, somatic
  • Adrenal adenoma, somatic
  • Parathyroid adenoma, somatic

Green MUTYH in Additional findings health related - adult specific


Version 1.0

Component of the following Super Panels:

  • Additional findings health related - adults
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Other
    Phenotypes
    • Bowel cancer predisposition
    • MYH-associated polyposis
    • Adult only
    Tags
    • adult-onset

    Green MUTYH in Additional findings health related - CNV analysis adult specific


    Version 1.0

    Component of the following Super Panels:

  • Additional findings health related - CNV analysis adults
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Other
    • Expert Review Green
    Phenotypes
    • Adult only
    • Bowel cancer predisposition
    • MYH-associated polyposis
    Tags
    • adult-onset