Progressive cardiac conduction disease

Gene: ANK2

Red List (low evidence)

ANK2 (ankyrin 2)
EnsemblGeneIds (GRCh38): ENSG00000145362
EnsemblGeneIds (GRCh37): ENSG00000145362
OMIM: 106410, Gene2Phenotype
ANK2 is in 13 panels

3 reviews

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Comment on phenotypes: This gene is also associated with Cardiac arrhythmia, ankyrin-B-related 600919; Long QT syndrome 4 600919
Created: 2 Mar 2021, 3:54 p.m. | Last Modified: 2 Mar 2021, 3:54 p.m.
Panel Version: 1.30
Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Red on this panel.
Created: 2 Dec 2019, 10:38 a.m. | Last Modified: 2 Dec 2019, 10:38 a.m.
Panel Version: 0.30

James Eden (Manchester)

Red List (low evidence)

Little literature associating this gene with conduction disease in particular.
Created: 2 Oct 2019, 10:07 a.m. | Last Modified: 2 Oct 2019, 10:07 a.m.
Panel Version: 0.28

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Cardiac arrhythmia, ankyrin-B-related 600919; Long QT syndrome 4 600919

Publications

Rebecca Whittington (South West GLH)

Red List (low evidence)

Cardiac arrhythmia, ankyrin-B-related (600919), Long QT syndrome 4 (600919)
Created: 25 Mar 2019, 4:30 p.m.
Can be associated with Bradycardia. 27785597 - 1 report on HGMD
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

History Filter Activity

2 Mar 2021, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: ANK2 were changed from to Heart conduction disease, MONDO:0000992

2 Mar 2021, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: ANK2 were set to

21 Feb 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ellen McDonagh (Genomics England Curator)

gene: ANK2 was added gene: ANK2 was added to Progressive cardiac conduction disease. Sources: South West GLH Mode of inheritance for gene: ANK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted