Intestinal failure or congenital diarrhoea
Gene: NEUROG3The rating of this gene has been updated following NHS Genomic Medicine Serviceapproval.Created: 8 Mar 2022, 11:44 a.m. | Last Modified: 8 Mar 2022, 11:44 a.m.
Panel Version: 1.48
Comment on list classification: This gene is associated with a relevant phenotype in OMIM but not Gene2Phenotype. There is enough evidence to support a gene-disease association. This gene should be rated Green at the next review.Created: 12 Apr 2021, 12:13 p.m. | Last Modified: 12 Apr 2021, 12:13 p.m.
Panel Version: 1.30
Multiple families reported with malabsorptive diarrhoea +/- neonatal diabetes.
Sources: Expert ReviewCreated: 5 Jan 2021, 1:51 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Diarrhoea 4, malabsorptive, congenital, MIM# 610370
Publications
Tag Q2_21_rating was removed from gene: NEUROG3.
Source Expert Review Green was added to NEUROG3. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: neurog3 has been classified as Amber List (Moderate Evidence).
Tag Q2_21_rating tag was added to gene: NEUROG3.
Phenotypes for gene: NEUROG3 were changed from Diarrhoea 4, malabsorptive, congenital, MIM# 610370 to Diarrhoea 4, malabsorptive, congenital, OMIM:610370
gene: NEUROG3 was added gene: NEUROG3 was added to Intestinal failure. Sources: Expert Review Mode of inheritance for gene: NEUROG3 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: NEUROG3 were set to 16855267; 32574610; 28724572; 21490072 Phenotypes for gene: NEUROG3 were set to Diarrhoea 4, malabsorptive, congenital, MIM# 610370 Review for gene: NEUROG3 was set to GREEN