Rare anaemia
Gene: TF
Gene rating submitted by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group.Created: 18 Feb 2019, 2:24 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Atransferrinemia, 209300; Congenital hypotransferrinemia
Gene rating submitted by Mandy Nesbitt Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Trust January 2019 on behalf of Yorkshire and North East GLH for the GMS Haematology specialist test group.Created: 14 Feb 2019, 4:04 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
209300 Congenital hypotransferrinemia
Comment on list classification: Upgraded from Amber to Green. As discussed with the GMS Haematology Specialist Test Group at workshop 2nd July 2019. All agreed that there is enough evidence to rate this gene Green.Created: 22 Jul 2019, 3:29 p.m. | Last Modified: 22 Jul 2019, 3:29 p.m.
Panel Version: 0.47
Discrepant reviews, to be discussed at July workshop to agree rating.Created: 22 Jul 2019, 3:29 p.m. | Last Modified: 22 Jul 2019, 3:29 p.m.
Panel Version: 0.46
Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: TF; Suggested initial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Phenotypes: Atransferrinemia, 209300;Congenital hypotransferrinemia; PMID(s): none submittedCreated: 18 Feb 2019, 2:28 p.m.
Initial gene list (Consensus Genes for Panels_Haem_SHEFFIELD-29.01.2019.xlsx) collated by Mandy Nesbitt Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Trust January 2019 on behalf of Yorkshire and North East GLH for the GMS Haematology specialist test group. Gene Symbol submitted: TF; Suggested intial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Phenotypes: 209300 Congenital hypotransferrinemia; PMID(s): none submittedCreated: 14 Feb 2019, 4:05 p.m.
Initial gene list (Consensus Genes for Panels 17.12.18_Haem_WWMGLH_v3.xlxs) collated by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group. Gene Symbol submitted: TF; Suggested intial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Phenotypes: Atransferrinemia, 209300;Congenital hypotransferrinemia; PMID(s): 11110675;3472216;10660486;8187613;1862777; Comments: Useful for phenotypic interpretationCreated: 6 Feb 2019, 12:14 p.m.
Gene rating submitted by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group.Created: 6 Feb 2019, 12:13 p.m.
Gene: tf has been classified as Green List (High Evidence).
Added phenotypes Atransferrinemia, 209300; Congenital hypotransferrinemia for gene: TF
Source North West GLH was added to TF.
Added phenotypes 209300 Congenital hypotransferrinemia for gene: TF
Source Yorkshire and North East GLH was added to TF.
Source NHS GMS was added to TF.
Source Expert Review Amber was added to TF. Mode of inheritance for gene TF was changed from to BIALLELIC, autosomal or pseudoautosomal Added phenotypes Atransferrinemia, 209300; Congenital hypotransferrinemia for gene: TF Publications for gene TF were changed from to 3472216; 1862777; 11110675; 8187613; 10660486 Rating Changed from Red List (low evidence) to Amber List (moderate evidence)
gene: TF was added gene: TF was added to Rare anaemia. Sources: Wessex and West Midlands GLH Mode of inheritance for gene: TF was set to