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  2. Cytopenia - NOT Fanconi anaemia
  3. FCGR3B
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Cytopenia - NOT Fanconi anaemia

Gene: FCGR3B

Red List (low evidence)
FCGR3B (Fc fragment of IgG receptor IIIb)
EnsemblGeneIds (GRCh38): ENSG00000162747
EnsemblGeneIds (GRCh37): ENSG00000162747
OMIM: 610665, Gene2Phenotype
FCGR3B is in 4 panels

4 reviews

Arina Puzriakova (Genomics England Curator)

Comment on list classification: Demoted from Amber to Red inline with review by Dmitrijs Rots.

Also note review from Helen Brittain (Genomics England Clinical Team) on 100K panel Cytopenias and congenital anaemias (159) from 9 Mar 2017:

"Relevant phenotype affects neutrophils only, on a transient basis owing to presence of antibodies in mother and antigen in fetus (as a result of different genetic factors in father and mother.). Therefore not a germline condition associated with mutations in the child."
Created: 17 Apr 2024, 10:13 a.m. | Last Modified: 17 Apr 2024, 10:13 a.m.
Panel Version: 3.32
Created: 17 Apr 2024, 10:13 a.m.
Last Modified: 17 Apr 2024, 10:13 a.m.
Panel version: 3.32

Dmitrijs Rots (Children's Clinical University Hospital)

Red List (low evidence)

Cannot find sufficient evidence for being in the panel (even as amber). Only association-level evidence, not reaching monogenic level (e.g. https://pubmed.ncbi.nlm.nih.gov/36754570/)
Created: 26 Jan 2024, 10:35 a.m. | Last Modified: 26 Jan 2024, 10:35 a.m.
Panel Version: 3.21
Created: 26 Jan 2024, 10:35 a.m.
Last Modified: 26 Jan 2024, 10:35 a.m.
Panel version: 3.21

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (Consensus Genes for Panels 17.12.18_Haem_WWMGLH_v3.xlxs) collated by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group. Gene Symbol submitted: FCGR3B; Suggested intial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: Other - please specify in evaluation comments; Phenotypes: Neutropenia,alloimmuneneonatal; PMID(s): none submitted
Created: 6 Feb 2019, 3:13 p.m.
Created: 6 Feb 2019, 3:13 p.m.

Panel version: 0.6

Carl Fratter (Oxford University Hospitals NHS Trust)

I don't know

Gene rating submitted by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group.
Created: 6 Feb 2019, 3:12 p.m.
Created: 6 Feb 2019, 3:12 p.m.

Panel version: 0.5

Details

Mode of Inheritance
Other - please specify in evaluation comments
Sources
  • Expert Review Red
  • NHS GMS
  • Wessex and West Midlands GLH
Phenotypes
  • Neutropenia,alloimmuneneonatal
OMIM
610665
Clinvar variants
Variants in FCGR3B
Penetrance
None
Panels with this gene

History Filter Activity

17 Apr 2024, Gel status: 1

Entity classified by Genomics England curator

Arina Puzriakova (Genomics England Curator)

Gene: fcgr3b has been classified as Red List (Low Evidence).

6 Feb 2019, Gel status: 2

Added New Source

Louise Daugherty (Genomics England Curator)

Source NHS GMS was added to FCGR3B.

6 Feb 2019, Gel status: 2

Added New Source, Set mode of inheritance, Set Phenotypes, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Amber was added to FCGR3B. Mode of inheritance for gene FCGR3B was changed from to Other - please specify in evaluation comments Added phenotypes Neutropenia,alloimmuneneonatal for gene: FCGR3B Rating Changed from Red List (low evidence) to Amber List (moderate evidence)

6 Feb 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: FCGR3B was added gene: FCGR3B was added to Cytopenia - NOT Fanconi anaemia. Sources: Wessex and West Midlands GLH Mode of inheritance for gene: FCGR3B was set to