Cytopenia - NOT Fanconi anaemia
Gene: FCGR3BComment on list classification: Demoted from Amber to Red inline with review by Dmitrijs Rots.
Also note review from Helen Brittain (Genomics England Clinical Team) on 100K panel Cytopenias and congenital anaemias (159) from 9 Mar 2017:
"Relevant phenotype affects neutrophils only, on a transient basis owing to presence of antibodies in mother and antigen in fetus (as a result of different genetic factors in father and mother.). Therefore not a germline condition associated with mutations in the child."Created: 17 Apr 2024, 10:13 a.m. | Last Modified: 17 Apr 2024, 10:13 a.m.
Panel Version: 3.32
Cannot find sufficient evidence for being in the panel (even as amber). Only association-level evidence, not reaching monogenic level (e.g. https://pubmed.ncbi.nlm.nih.gov/36754570/)Created: 26 Jan 2024, 10:35 a.m. | Last Modified: 26 Jan 2024, 10:35 a.m.
Panel Version: 3.21
Initial gene list (Consensus Genes for Panels 17.12.18_Haem_WWMGLH_v3.xlxs) collated by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group. Gene Symbol submitted: FCGR3B; Suggested intial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: Other - please specify in evaluation comments; Phenotypes: Neutropenia,alloimmuneneonatal; PMID(s): none submittedCreated: 6 Feb 2019, 3:13 p.m.
Gene rating submitted by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group.Created: 6 Feb 2019, 3:12 p.m.
Gene: fcgr3b has been classified as Red List (Low Evidence).
Source NHS GMS was added to FCGR3B.
Source Expert Review Amber was added to FCGR3B. Mode of inheritance for gene FCGR3B was changed from to Other - please specify in evaluation comments Added phenotypes Neutropenia,alloimmuneneonatal for gene: FCGR3B Rating Changed from Red List (low evidence) to Amber List (moderate evidence)
gene: FCGR3B was added gene: FCGR3B was added to Cytopenia - NOT Fanconi anaemia. Sources: Wessex and West Midlands GLH Mode of inheritance for gene: FCGR3B was set to