Inherited predisposition to acute myeloid leukaemia (AML)
Gene: ANKRD26
On the current WWMGLH Familial MDS/AML panel. In WHO classification. Testing recommended in AML ELN guidelines and by Obrochta and Godley (Best Pract Res Clin Haematol. 2018 Dec;31(4):373-378).Created: 7 Mar 2019, 11:23 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
610855
Publications
Variants in this GENE are reported as part of current diagnostic practice
Gene rating submitted by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group.Created: 18 Feb 2019, 2:06 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
610855
Comment on list classification: As discussed in the GMS Haematology Specialist Test Group webex call 8th March 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene Green.Created: 18 Mar 2019, 4:30 p.m.
Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: ANKRD26; Suggested initial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 610855; PMID(s): none submittedCreated: 18 Feb 2019, 2:12 p.m.
Initial gene list (Consensus Genes for Panels 17.12.18_Haem_WWMGLH_v3.xlxs) collated by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group. Gene Symbol submitted: CEBPA; Suggested intial gene rating: not submitted; Are variants in this gene part of your current diagnostic practice? not submitted; MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 116897 (OMIN gene description ID); 601626 (OMIM phenotype description ID); PMID(s): 15575056; 23926458Created: 5 Feb 2019, 8:10 p.m.
Gene rating (none submitted) by Carl Fratter Oxford Medical Genetics Laboratories January 2019 on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group.Created: 5 Feb 2019, 8:08 p.m.
Phenotypes for gene: ANKRD26 were changed from 610855; 610855 (OMIN gene description ID); not submitted (OMIM phenotype description ID) to Thrombocytopenia 2, OMIM:188000; Acute myeloid leukemia, MONDO:0018874
Publications for gene: ANKRD26 were set to 23926458
Gene: ankrd26 has been classified as Green List (High Evidence).
Added phenotypes 610855 for gene: ANKRD26
Source North West GLH was added to ANKRD26.
Source NHS GMS was added to ANKRD26. Added phenotypes 610855 (OMIN gene description ID); not submitted (OMIM phenotype description ID) for gene: ANKRD26
Source Expert Review Amber was added to ANKRD26. Mode of inheritance for gene ANKRD26 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Added phenotypes 610855 (OMIN gene description ID); not submitted (OMIM phenotype description ID) for gene: ANKRD26 Publications for gene ANKRD26 were changed from to 23926458 Rating Changed from Red List (low evidence) to Amber List (moderate evidence)
gene: ANKRD26 was added gene: ANKRD26 was added to Inherited predisposition to acute myeloid leukaemia (AML). Sources: Wessex and West Midlands GLH Mode of inheritance for gene: ANKRD26 was set to