Rare genetic inflammatory skin disordersGene: CSTA
Susceptibility to psoriasis / atopic dermatitis - insufficient evidence for inclusion. Peeling skin syndrome - sufficient evidence, but not clinically appropriate for ISD panel? (Gene is green on PPK & EB)
Created: 12 Dec 2019, 3:08 p.m. | Last Modified: 12 Dec 2019, 3:08 p.m.
Panel Version: 0.21
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
susceptility to atopic dermatitis; Exfoliative ichthyosis/acral peeling skin syndrome; susceptibility to psoriasis
This gene was part of an initial gene list collated by Thomas Cullup, GOSH and Veronica Kinsler, UCL, 25.Jan.2019 on behalf of the GMS Skin Specialist Test Group. Gene Symbol submitted: CSTA; Suggested initial gene rating: Green; Evidence for inclusion: none provided; Evidence for exclusion: none provided; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none provided.
Created: 31 Jan 2019, 2:02 p.m.
Variants in this GENE are reported as part of current diagnostic practice
Source Expert Review Amber was added to CSTA. Added phenotypes susceptibility to psoriasis; Exfoliative ichthyosis/acral peeling skin syndrome; susceptility to atopic dermatitis for gene: CSTA Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
Source London North GLH was added to CSTA.
gene: CSTA was added gene: CSTA was added to Rare genetic inflammatory skin disorders. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: CSTA was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: CSTA were set to susceptility to atopic dermatitis; Exfoliative ichthyosis/acral peeling skin syndrome; susceptibility to psoriasis